铜催化的叠氮-炔环加成、乌尔曼型 C-N 偶联和分子内直接芳基化反应。
Copper-catalyzed tandem azide-alkyne cycloaddition, Ullmann type C-N coupling, and intramolecular direct arylation.
机构信息
Department of Chemistry, Birla Institute of Technology and Science, Pilani, 333031, India.
出版信息
Org Lett. 2013 Sep 6;15(17):4304-7. doi: 10.1021/ol401655r. Epub 2013 Aug 16.
PMID:23947761
Abstract
A ligand-free copper-catalyzed tandem azide-alkyne cycloaddition (CuAAC), Ullmann-type C-N coupling, and intramolecular direct arylation has been described. The designed strategy resulted in the synthesis of a novel trazole-fused azaheterocycle framework. The reaction gave good yields (59-77%) of 1,2,3-triazole-fused imidazo[1,2-a]pyridines in a single step.
摘要
一种无配体的铜催化叠氮-炔环加成（CuAAC）、Ullmann 型 C-N 偶联和分子内直接芳基化反应已被描述。所设计的策略导致了新型三唑并稠合氮杂环体系的合成。该反应以一步法得到了良好收率（59-77%）的 1,2,3-三唑并咪唑并[1,2-a]吡啶。
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