Mangan Mary E, Williams Jennifer M, Kuhn Robert M, Lathe Warren C
OpenHelix LLC, Bainbridge Island, Washington.
Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California.
Curr Protoc Mol Biol. 2014 Jul 1;107:19.9.1-19.9.36. doi: 10.1002/0471142727.mb1909s107.
Electronic data resources can enable molecular biologists to quickly get information from around the world that a decade ago would have been buried in papers scattered throughout the library. The ability to access, query, and display these data makes benchwork much more efficient and drives new discoveries. Increasingly, mastery of software resources and corresponding data repositories is required to fully explore the volume of data generated in biomedical and agricultural research, because only small amounts of data are actually found in traditional publications. The UCSC Genome Browser provides a wealth of data and tools that advance understanding of genomic context for many species, enable detailed analysis of data, and provide the ability to interrogate regions of interest across disparate data sets from a wide variety of sources. Researchers can also supplement the standard display with their own data to query and share this with others. Effective use of these resources has become crucial to biological research today, and this unit describes some practical applications of the UCSC Genome Browser.
电子数据资源能让分子生物学家迅速获取来自世界各地的信息，而在十年前，这些信息还被埋没在散落于图书馆各处的纸质文献中。访问、查询和显示这些数据的能力使实验工作效率大幅提高，并推动了新发现。越来越多地，要充分探索生物医学和农业研究中产生的数据量，就需要掌握软件资源和相应的数据存储库，因为传统出版物中实际能找到的数据量很少。加州大学圣克鲁兹分校基因组浏览器提供了丰富的数据和工具，可增进对许多物种基因组背景的理解，实现对数据的详细分析，并能跨来自各种来源的不同数据集查询感兴趣的区域。研究人员还可以用自己的数据补充标准显示内容，以便查询并与他人共享。如今，有效利用这些资源对生物学研究至关重要，本单元将介绍加州大学圣克鲁兹分校基因组浏览器的一些实际应用。
