Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.
Dev Cell. 2014 Dec 8;31(5):543-58. doi: 10.1016/j.devcel.2014.10.022. Epub 2014 Nov 26.
The dermal papilla (DP) provide instructive signals required to activate epithelial progenitors and initiate hair follicle regeneration. DP cell numbers fluctuate over the hair cycle, and hair loss is associated with gradual depletion/atrophy of DP cells. How DP cell numbers are maintained in healthy follicles remains unclear. We performed in vivo fate mapping of adult hair follicle dermal sheath (DS) cells to determine their lineage relationship with DP and found that a subset of DS cells are retained following each hair cycle, exhibit self-renewal, and repopulate the DS and the DP with new cells. Ablating these hair follicle dermal stem cells and their progeny retarded hair regrowth and altered hair type specification, suggesting that they function to modulate normal DP function. This work identifies a bipotent stem cell within the adult hair follicle mesenchyme and has important implications toward restoration of hair growth after injury, disease, and aging.
真皮乳头（DP）提供了激活上皮祖细胞和启动毛囊再生所需的指导信号。DP 细胞数量在毛发周期中波动，脱发与 DP 细胞逐渐耗竭/萎缩有关。在健康的毛囊中，DP 细胞数量是如何维持的仍不清楚。我们对成年毛囊真皮鞘（DS）细胞进行了体内命运图谱分析，以确定它们与 DP 的谱系关系，发现一组 DS 细胞在每个毛发周期后被保留，表现出自我更新，并利用新细胞重新填充 DS 和 DP。这些毛囊真皮干细胞及其后代的缺失会延迟毛发生长和改变毛发类型的特化，表明它们的功能是调节 DP 的正常功能。这项工作鉴定了成年毛囊间充质中的一种双潜能干细胞，对损伤、疾病和衰老后毛发再生具有重要意义。
