Daly K, De Lima H, Kato H, Sordillo E M, Convit J, Reyes-Jaimes O, Zerpa O, Paniz-Mondolfi A E
Fundación Jacinto Convit, Caracas, Venezuela.
Clin Exp Dermatol. 2014 Aug;39(6):708-12. doi: 10.1111/ced.12359. Epub 2014 Jul 1.
American cutaneous leishmaniasis is an endemic anthropozoonosis that exhibits a broad spectrum of clinical presentations. Intermediate/borderline disseminated cutaneous leishmaniasis is a distinct clinical condition that comprises cutaneous disease of a chronic nature, usually occurring as multiple lesions with or without mucosal involvement. The disease is usually caused by parasites of the subgenus Viannia, frequently occurs in context of an underlying disease, and is often resistant to standard antileishmanial therapy. We report a case that was refractory to standard therapy and other second-line drugs, but resolved after treatment with fluconazole, and review the use of fluconazole as a second-line drug in children.
美洲皮肤利什曼病是一种地方性人兽共患病，临床表现多种多样。中间型/边缘型播散性皮肤利什曼病是一种独特的临床病症，包括慢性皮肤疾病，通常表现为多个病灶，可伴有或不伴有黏膜受累。该病通常由维扬亚属寄生虫引起，常发生于潜在疾病背景下，且往往对标准抗利什曼治疗耐药。我们报告了1例对标准治疗和其他二线药物均难治，但经氟康唑治疗后痊愈的病例，并综述了氟康唑作为儿童二线药物的应用情况。
