精子发生过程中生殖细胞穿过生精上皮的运输
Germ cell transport across the seminiferous epithelium during spermatogenesis.
作者信息
Xiao Xiang, Mruk Dolores D, Wong Chris K C, Cheng C Yan
机构信息
The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York; and.
Department of Biology, Hong Kong Baptist University, Hong Kong, China.
出版信息
Physiology (Bethesda). 2014 Jul;29(4):286-98. doi: 10.1152/physiol.00001.2014.
Abstract
Transport of germ cells across the seminiferous epithelium is crucial to spermatogenesis. Its disruption causes infertility. Signaling molecules, such as focal adhesion kinase, c-Yes, c-Src, and intercellular adhesion molecules 1 and 2, are involved in these events by regulating actin-based cytoskeleton via their action on actin-regulating proteins, endocytic vesicle-mediated protein trafficking, and adhesion protein complexes. We critically evaluate these findings and provide a hypothetical framework that regulates these events.
摘要
生殖细胞穿过生精上皮的运输对于精子发生至关重要。其破坏会导致不育。信号分子，如粘着斑激酶、c-Yes、c-Src以及细胞间粘附分子1和2，通过作用于肌动蛋白调节蛋白、内吞小泡介导的蛋白质运输和粘附蛋白复合物来调节基于肌动蛋白的细胞骨架，从而参与这些过程。我们对这些发现进行了批判性评估，并提供了一个调节这些过程的假设框架。
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