Zhang Siwei, Zheng Rongshou, Zeng Hongmei, Chen Wanqing
National Cancer Center, National Center for Cancer Registries, Beijing 100021, China.
National Cancer Center, National Center for Cancer Registries, Beijing 100021, China. Email:
Zhonghua Yu Fang Yi Xue Za Zhi. 2014 May;48(5):355-60.
Using the incidence data from 1989 to 2008 of liver cancer from population in cancer registration areas in China, the differences and changes of gender, urban and rural areas for liver cancer incidence in different years were studied, and the mean age of incidence was analyzed.
The incidence data of liver cancer from National Cancer Registration database were sorted and checked. A total of 181 097 new liver cancer cases were collected, covering 711 843 051 person years from 1989 to 2008.Using Poisson regression model, Stratified by gender and areas, changes of incidence gender ratio, ratio of urban and rural, and mean age were analyzed.
After adjusting the age, the liver cancer incidence in male was about 3 times higher than that in females (ranging from 2.64-3.54), and the ratio change between male and female for the 20 years did not have statistically significant (P = 0.150). The incidence ratio between urban and rural areas has increased from 0.51 in 1989 to 0.61 in 2008 (P < 0.01). The mean ages of diagnosis for male and female increased from 57.14 years to 60.34 years, 61.69 years to 66.47 years, respectively from 1989 to 2008. The mean age of liver cancer diagnosis has increased in the 20 years (P < 0.01).
The liver cancer incidence between male and female did not change significantly among 20 years. The difference of liver cancer incidence between urban and rural areas has reduced, and the mean age of diagnosis was deferred.
利用中国癌症登记地区1989年至2008年人群肝癌发病数据，研究不同年份肝癌发病的性别、城乡差异及变化情况，并分析发病年龄均值。
整理并核查国家癌症登记数据库中的肝癌发病数据。共收集到181097例肝癌新发病例，覆盖1989年至2008年711843051人年。采用泊松回归模型，按性别和地区分层，分析发病性别比、城乡比及平均年龄的变化。
调整年龄后，男性肝癌发病率约为女性的3倍（范围为2.64 - 3.54），20年间男女发病率之比变化无统计学意义（P = 0.150）。城乡发病率之比从1989年的0.51升至2008年的0.61（P < 0.01）。1989年至2008年，男性和女性的诊断平均年龄分别从57.14岁增至60.34岁、从61.69岁增至66.47岁。20年间肝癌诊断平均年龄有所增加（P < 0.01）。
20年间男女肝癌发病率无显著变化。城乡肝癌发病率差异缩小，诊断平均年龄推迟。
