烧伤创面渗出液——一种未得到充分利用的资源。
The burn wound exudate-an under-utilized resource.
作者信息
Widgerow Alan D, King Kassandra, Tocco-Tussardi Ilaria, Banyard Derek A, Chiang Ryan, Awad Antony, Afzel Hassan, Bhatnager Shweta, Melkumyan Satenik, Wirth Garrett, Evans Gregory R D
机构信息
Director Center for Tissue Engineering, Plastic Surgery Dept, University of California, Irvine, United States.
Researcher Center for Tissue Engineering, Plastic Surgery Dept, University of California, Irvine, United States.
出版信息
Burns. 2015 Feb;41(1):11-7. doi: 10.1016/j.burns.2014.06.002. Epub 2014 Jun 27.
INTRODUCTION
The burn wound exudate represents the burn tissue microenvironment. Extracting information from the exudate relating to cellular components, signaling mediators and protein content can provide much needed data relating to the local tissue damage, depth of the wound and probable systemic complications. This review examines the scientific data extracted from burn wound exudates over the years and proposes new investigations that will provide useful information from this underutilized resource.
METHOD
A literature review was conducted using the electronic database PubMed to search for literature pertaining to burn wound or blister fluid analysis. Key words included burn exudate, blister fluid, wound exudate, cytokine burn fluid, subeschar fluid, cytokine burns, serum cytokines. 32 relevant articles were examined and 29 selected as relevant to the review. 3 papers were discarded due to questionable methodology or conclusions. The reports were assessed for their affect on management decisions and diagnostics. Furthermore, traditional blood level analysis of these mediators was made to compare the accuracy of blood versus exudate in burn wound management. Extrapolations are made for new possibilities of burn wound exudate analysis.
RESULTS
Studies pertaining to burn wound exudate, subeschar fluid and blister fluid analyses may have contributed to burn wound management decisions particularly related to escharectomies and early burn wound excision. In addition, information from these studies has the potential to impact on areas such as healing, scarring, burn wound conversion and burn wound depth analysis.
CONCLUSION
Burn wound exudate analysis has proven useful in burn wound management decisions. It appears to offer a far more accurate reflection of the burn wound pathophysiology than the traditional blood/serum investigations undertaken in the past. New approaches to diagnostics and treatment efficacy assessment are possible utilizing data from this fluid. Burn wound exudate is a useful, currently under-utilized resource that is likely to take a more prominent role in burn wound management.
引言
烧伤创面渗出液代表了烧伤组织的微环境。从渗出液中提取有关细胞成分、信号介质和蛋白质含量的信息，可以提供与局部组织损伤、伤口深度和可能的全身并发症相关的急需数据。本综述回顾了多年来从烧伤创面渗出液中提取的科学数据，并提出了新的研究方向，以便从这一未充分利用的资源中获取有用信息。
方法
使用电子数据库PubMed进行文献综述，以搜索与烧伤创面或水疱液分析相关的文献。关键词包括烧伤渗出液、水疱液、伤口渗出液、细胞因子烧伤液、焦痂下液、细胞因子烧伤、血清细胞因子。共检索到32篇相关文章，其中29篇被选为与本综述相关。3篇文章因方法或结论存疑而被剔除。对这些报告在管理决策和诊断方面的影响进行了评估。此外，还对这些介质进行了传统的血液水平分析，以比较血液和渗出液在烧伤创面管理中的准确性。对烧伤创面渗出液分析的新可能性进行了推断。
结果
有关烧伤创面渗出液、焦痂下液和水疱液分析的研究可能有助于烧伤创面管理决策，特别是与焦痂切除和早期烧伤创面切除相关的决策。此外，这些研究的信息有可能影响愈合、瘢痕形成、烧伤创面转变和烧伤创面深度分析等领域。
结论
烧伤创面渗出液分析已被证明在烧伤创面管理决策中有用。它似乎比过去进行的传统血液/血清检查更准确地反映了烧伤创面的病理生理学。利用这种液体的数据，有可能实现诊断和治疗效果评估的新方法。烧伤创面渗出液是一种有用的、目前未被充分利用的资源，可能在烧伤创面管理中发挥更重要的作用。
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