Kim Roderick Y, Fasi Anthony C, Feinberg Stephen E
Department of Surgery, Section of Oral and Maxillofacial Surgery, University of Michigan Medical School and School of Dentistry, Ann Arbor, MI, USA.
Ann Maxillofac Surg. 2014 Jan;4(1):4-8. doi: 10.4103/2231-0746.133064.
Craniofacial soft tissue reconstruction may be required following trauma, tumor resection, and to repair congenital deformities. Recent advances in the field of tissue engineering have significantly widened the reconstructive armamentarium of the surgeon. The successful identification and combination of tissue engineering, scaffold, progenitor cells, and physiologic signaling molecules has enabled the surgeon to design, recreate the missing tissue in its near natural form. This has resolved the issues like graft rejection, wound dehiscence, or poor vascularity. Successfully reconstructed tissue through soft tissue engineering protocols would help surgeon to restore the form and function of the lost tissue in its originality. This manuscript intends to provide a glimpse of the basic principle of tissue engineering, contemporary, and future direction of this field as applied to craniofacial surgery.
创伤、肿瘤切除术后以及修复先天性畸形可能需要进行颅面软组织重建。组织工程领域的最新进展显著拓宽了外科医生的重建手段。组织工程、支架、祖细胞和生理信号分子的成功识别与结合，使外科医生能够设计并以近乎自然的形式再造缺失的组织。这解决了诸如移植排斥、伤口裂开或血管供应不良等问题。通过软组织工程方案成功重建的组织将有助于外科医生原汁原味地恢复缺失组织的形态和功能。本文旨在简要介绍组织工程的基本原理、该领域在颅面外科中的当代应用及未来发展方向。
