Department of Experimental Psychology, University of Oxford, Oxford, Oxford OX1 3UD, United Kingdom, and
Department of Experimental Psychology, University of Oxford, Oxford, Oxford OX1 3UD, United Kingdom, and.
J Neurosci. 2014 Jul 2;34(27):9024-33. doi: 10.1523/JNEUROSCI.4465-13.2014.
Prediction error signals are fundamental to learning. Here, in mice, we show that aversive prediction signals are found in the hemodynamic responses and theta oscillations recorded from the basolateral amygdala. During fear conditioning, amygdala responses evoked by footshock progressively decreased, whereas responses evoked by the auditory cue that predicted footshock concomitantly increased. Unexpected footshock evoked larger amygdala responses than expected footshock. The magnitude of the amygdala response to the footshock predicted behavioral responses the following day. The omission of expected footshock led to a decrease below baseline in the amygdala response suggesting a negative aversive prediction error signal. Thus, in mice, amygdala activity conforms to temporal difference models of aversive learning.
预测误差信号对学习至关重要。在这里，我们在小鼠中表明，厌恶预测信号存在于从基底外侧杏仁核记录的血流动力学反应和θ振荡中。在恐惧条件反射中，由足部电击引起的杏仁核反应逐渐减少，而由预测足部电击的听觉提示引起的反应则相应增加。出乎意料的足部电击引起的杏仁核反应大于预期的足部电击。对足部电击的杏仁核反应的幅度预测了第二天的行为反应。预期足部电击的缺失导致杏仁核反应低于基线下降，表明存在负性厌恶预测误差信号。因此，在小鼠中，杏仁核活动符合厌恶学习的时间差模型。
