中国新疆维吾尔自治区南部野生脊髓灰质炎病毒疫情期间脊髓灰质炎抗体血清学调查
Sero-survey of polio antibodies during wild poliovirus outbreak in southern Xinjiang Uygur Autonomous Region, China.
作者信息
Wang Hai-Bo, Zhu Shuang-Li, Zheng Jing-Shan, Gou Ai-Li, Cui Hui, Zhang Yong, Ning Gui-Jun, Fan Chun-Xiang, Chen Yuan-Sheng, Li Ke-Li, Yuan Ping, Ma Chao, Ma Jing, Zheng Hui, Fan Xin-Chun, Li Xin-Lan, Tang Hai-Shu, Li Xiao-Lei, Zhang Fan, Yan Dong-Mei, Wang Dong-Yan, Cui Zhi-Qiang, Ren Li-Ping, Zhu Hui, Wang Hui-Ling, Jiang Xiao-Hong, An Hong-Qiu, Liu Yang, Li Jing, Xu Wen-Bo, Wen Ning, Xu Ai-Qiang, Luo Hui-Ming
机构信息
Expanded Program on Immunization, Chinese Center for Disease Control and Prevention, Beijing, China.
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
出版信息
PLoS One. 2014 Jul 3;9(7):e80069. doi: 10.1371/journal.pone.0080069. eCollection 2014.
BACKGROUND
After being polio free for more than 10 years, an outbreak following importation of wild poliovirus (WPV) was confirmed in Xinjiang Uygur Autonomous Region, China, in 2011.
METHODS
A cross-sectional study was conducted prior to supplementary immunization activities (SIAs), immediately after the confirmation of the WPV outbreak. In selected prefectures, participants aged ≤ 60 years old who visited hospitals at county-level or above to have their blood drawn for reasons not related to the study, were invited to participate in our study. Antibody titers ≥ 8 were considered positive.
RESULTS
Among the 2,611 participants enrolled, 2,253 (86.3%), 2,283 (87.4%), and 1,989 (76.2%) were seropositive to P1, P2 and P3 respectively, and 1744 (66.8%) participants were seropositive to all the three serotypes. Lower antibody seropositivities and geometric mean titers were observed in children <1 year of age and in adults aged 15-39 years.
CONCLUSION
Serosurveys to estimate population immunity in districts at high risk of polio importation might be useful to gauge underlying population immunity gaps to polio and possibly to guide preparedness and response planning. Consideration should be given to older children and adults during polio risk assessment planning and outbreak response.
背景
中国新疆维吾尔自治区在保持无脊髓灰质炎状态超过10年后，于2011年确认发生了一起输入野生脊髓灰质炎病毒（WPV）后的疫情。
方法
在确认WPV疫情后，于补充免疫活动（SIAs）之前开展了一项横断面研究。在选定的地区，邀请年龄≤60岁、因与研究无关的原因前往县级及以上医院抽血的参与者参与我们的研究。抗体滴度≥8被视为阳性。
结果
在纳入的2611名参与者中，对P1、P2和P3血清型呈血清阳性的分别有2253人（86.3%）、2283人（87.4%）和1989人（76.2%），对所有三种血清型均呈血清阳性的参与者有1744人（66.8%）。在<1岁的儿童和15 - 39岁的成年人中观察到较低的抗体血清阳性率和几何平均滴度。
结论
在脊髓灰质炎输入风险高的地区进行血清学调查以评估人群免疫力，可能有助于衡量人群对脊髓灰质炎的潜在免疫差距，并可能指导防范和应对计划。在脊髓灰质炎风险评估规划和疫情应对期间，应考虑大龄儿童和成年人。
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