2011年中国新疆维吾尔自治区输入性野生脊髓灰质炎病毒引发的疫情。
An outbreak following importation of wild poliovirus in Xinjiang Uyghur Autonomous Region, China, 2011.
作者信息
Wang Hai-Bo, Yu Wen-Zhou, Wang Xin-Qi, Wushouer Fuerhati, Wang Jian-Ping, Wang Dong-Yan, Cui Fu-Qiang, Zheng Jing-Shan, Wen Ning, Ji Yi-Xin, Fan Chun-Xiang, Wang Hui-Ling, Ning Gui-Jun, Huang Guo-Hong, Yan Dong-Mei, Su Qi-Ru, Liu Da-Wei, Zhang Guo-Min, Reilly Kathleen H, Ning Jing, Fu Jian-Ping, Mi Sha-Sha, Luo Hui-Ming, Yang Wei-Zhong
机构信息
Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing, 100050, PR China.
Peking University Clinical Research Institute, Xueyuan Rd 38#, Haidian District, Beijing, 100191, PR China.
出版信息
BMC Infect Dis. 2015 Jan 31;15:34. doi: 10.1186/s12879-015-0761-y.
BACKGROUND
After more than 10 years without a case of wild poliovirus (WPV) in China, an outbreak occurred in 2011 in Xinjiang Uyghur Autonomous Region.
METHODS
Acute flaccid paralysis (AFP) case surveillance was strengthened with epidemiological investigations and specimen collection and serological surveys were conducted among hospitalized patients.
RESULTS
There were 21 WPV cases and 23 clinical compatible polio cases reported. WPV was isolated from 14 contacts of AFP cases and 13 in the healthy population. Incidence of WPV and clinical compatible polio cases were both highest among children <1 years, however, 24/44 (54.5%) polio cases were reported among adults aged 15-39 years.
CONCLUSIONS
High coverage of routine immunization should be maintained among children until WPV transmission is globally eradicated. Expansion of AFP case surveillance and use of serologic surveys to estimate population immunity should be conducted rapidly to guide preparedness and response planning for future WPV outbreaks.
背景
在中国无野生脊髓灰质炎病毒（WPV）病例超过10年后，2011年新疆维吾尔自治区发生了疫情。
方法
加强急性弛缓性麻痹（AFP）病例监测，开展流行病学调查，并对住院患者进行标本采集和血清学调查。
结果
报告了21例WPV病例和23例临床诊断符合脊髓灰质炎病例。从14例AFP病例的接触者和13例健康人群中分离出WPV。WPV和临床诊断符合脊髓灰质炎病例的发病率在1岁以下儿童中均最高，然而，44例脊髓灰质炎病例中有24例（54.5%）报告发生在15至39岁的成年人中。
结论
在全球根除WPV传播之前，应保持儿童常规免疫的高覆盖率。应迅速扩大AFP病例监测范围，并利用血清学调查评估人群免疫力，以指导未来WPV疫情的防范和应对规划。
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