Jones Siân Bodfel, Davies Maria, Chapman Nicholas, Willson Richard, Hornby Kate, Joiner Andrew, West Nicola X
Periodontology, Clinical Trials Unit, Bristol Dental School, Lower Maudlin St, Bristol, BS1 2LY, UK.
Periodontology, Clinical Trials Unit, Bristol Dental School, Lower Maudlin St, Bristol, BS1 2LY, UK.
J Dent. 2014 Jun;42 Suppl 1:S46-52. doi: 10.1016/S0300-5712(14)50007-3.
To introduce a new interproximal mineralisation model and to investigate the effectiveness of novel toothpaste and dual phase gel formulations to remineralise acid softened enamel in a simulated interproximal environment.
Specimens were positioned opposite each other with an approximately 100 μm space between enamel surfaces to simulate an interproximal environment. Target specimens were demineralised in 1% (w/v) citric acid, pH3.75. Specimens were daily immersed in artificial saliva (AS) for 1h, treated with formulations, re-immersed in AS for 6h, re-treated and re-immersed in AS for a further 1h. Study 1 evaluated prototype calcium silicate/phosphate fluoride toothpaste formulations. Study 2 evaluated novel calcium silicate/phosphate fluoride toothpaste and dual phase gel formulations. Both studies contained fluoridated and non-fluoridated controls. The surface microhardness of each target enamel block was measured following demineralisation and following days three, seven and fourteen for study one and after days one, three and seven for study two.
This new mineralisation model was able to show increased remineralisation from calcium silicate/phosphate fluoride prototype formulations over fluoridated formulations alone, after three and seven days of treatment. Using this new model, the combined application of novel calcium silicate/phosphate fluoride toothpaste and novel calcium silicate/phosphate fluoride dual phase gel showed the greatest amount of remineralisation, which was significantly greater than sodium fluoride and non-fluoride controls.
Employing a new interproximal mineralisation model successfully determined the remineralisation potential of novel calcium silicate/phosphate fluoride oral healthcare formulations.
Modifying a mineralisation model to include specimens positioned in an interproximal environment allows us to better understand the remineralisation potential of oral healthcare products. It is important to minimise mineral loss at interproximal sites as the enamel within these areas is thinner than the rest of the crown.
引入一种新的邻面矿化模型，并研究新型牙膏和双相凝胶配方在模拟邻面环境中对酸软化牙釉质再矿化的有效性。
将标本彼此相对放置，牙釉质表面之间留出约100μm的空间以模拟邻面环境。将目标标本在pH3.75的1%（w/v）柠檬酸中脱矿。标本每天在人工唾液（AS）中浸泡1小时，用配方处理，再在AS中浸泡6小时，再次处理，然后再在AS中浸泡1小时。研究1评估了硅酸钙/磷酸氟原型牙膏配方。研究2评估了新型硅酸钙/磷酸氟牙膏和双相凝胶配方。两项研究均包含含氟和不含氟的对照。在脱矿后以及研究1的第3、7和14天以及研究2的第1、3和7天后，测量每个目标牙釉质块的表面显微硬度。
在处理3天和7天后，这种新的矿化模型能够显示出硅酸钙/磷酸氟原型配方比单独的含氟配方有更高的再矿化率。使用这种新模型，新型硅酸钙/磷酸氟牙膏和新型硅酸钙/磷酸氟双相凝胶的联合应用显示出最大量的再矿化，显著大于氟化钠和无氟对照。
采用新的邻面矿化模型成功确定了新型硅酸钙/磷酸氟口腔护理配方的再矿化潜力。
修改矿化模型以纳入放置在邻面环境中的标本，使我们能够更好地了解口腔护理产品的再矿化潜力。尽量减少邻面部位的矿物质流失很重要，因为这些区域的牙釉质比牙冠的其他部分更薄。
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