Department of Paediatric Dentistry, Leeds School of Dentistry, University of Leeds, UK.
Department of Paediatric Dentistry, Leeds School of Dentistry, University of Leeds, UK; Faculty of Dentistry, National University of Singapore, Singapore.
J Dent. 2017 Nov;66:37-44. doi: 10.1016/j.jdent.2017.08.013. Epub 2017 Aug 30.
To investigate in vitro the effect of MI Paste, MI Paste Plus and 2800ppm fluoride (F) toothpaste (TP) on the remineralisation of enamel subsurface lesions and to compare these to the effect of 1450ppm and 0ppm F toothpastes.
Enamel subsurface lesions were created in bovine enamel slabs (n=120) which were assigned randomly to five groups; (1) 0ppm F TP, (2) 1450ppm F TP, (3) 2800ppm F TP, (4) 1450ppm F TP+MI Paste (Tooth Mousse-TM,10% w/v CPP-ACP) and (5) 1450ppm F TP+MI Paste Plus (Tooth Mousse Plus,10% w/v CPP-ACP, 900ppm F as 0.2% w/w sodium fluoride). The enamel slabs were subjected to a pH cycling regimen for 21days. Quantitative Light-induced Fluorescence (QLF) images were taken and analysed. Data analysis was carried out using one way ANOVA.
In all groups, both ΔF (percentage fluorescence loss) and ΔQ (ΔF times the area) values improved significantly within the same group after the treatment. In addition, the mean difference in ΔF of the non-fluoride control group was significantly lower than all other groups but not for the 2800ppm F group. Whereas the mean difference in ΔQ of the non-fluoride control of group was significantly lower when compared with all other groups (p<0.05).
Both MI Paste and MI Paste Plus when used in conjunction with 1450ppm F did not show a significant increase in efficacy for the remineralisation of bovine enamel subsurface lesions in the model used in this study.
Newer preventive agents such as MI paste and MI paste plus are advocated as promoting remineralisation when used in addition to routine oral care. This in vitro study shows that they may have a limited value in promoting remineralisation over and above that of 1450ppm F toothpaste used twice a day.
研究 MI Paste、MI Paste Plus 和 2800ppm 氟化物（F）牙膏（TP）对牙釉质表面下病变再矿化的体外影响，并将其与 1450ppm 和 0ppm F 牙膏的效果进行比较。
在牛牙釉质平板上制备牙釉质表面下病变（n=120），将其随机分配到五个组中；（1）0ppm F TP，（2）1450ppm F TP，（3）2800ppm F TP，（4）1450ppm F TP+MI Paste（牙沫-TM，10% w/v CPP-ACP）和（5）1450ppm F TP+MI Paste Plus（牙沫 Plus，10% w/v CPP-ACP，900ppm F 作为 0.2% w/w 氟化钠）。牙釉质平板经过 21 天的 pH 循环处理。拍摄并分析定量光致荧光（QLF）图像。使用单向方差分析进行数据分析。
在所有组中，同一组治疗后，ΔF（荧光损失百分比）和ΔQ（ΔF 乘以面积）值均显著提高。此外，非氟化物对照组的平均差异ΔF 显著低于其他所有组，但不低于 2800ppm F 组。而当与所有其他组相比时，非氟化物对照组的平均差异ΔQ 显著降低（p<0.05）。
在本研究中使用的模型中，当与 1450ppm F 一起使用时，MI Paste 和 MI Paste Plus 并未显示出对牛牙釉质表面下病变再矿化的功效显著增加。
提倡使用 MI 糊剂和 MI 糊剂 Plus 等新型预防剂在常规口腔护理之外促进再矿化。这项体外研究表明，与每天使用两次的 1450ppm F 牙膏相比，它们在促进再矿化方面的价值可能有限。
