Bourin P, Mansour I, Levi F, Villette J M, Roué R, Fiet J, Rouger P, Doinel C
(I.N.S.E.R.M. n. U 76), Paris.
C R Acad Sci III. 1989;308(16):431-6.
Circadian rhythms in circulating B and T (CD3, CD4, CD8) lymphocyte subsets and in plasma cortisol were studied in 13 HIV-infected men and 14 healthy male controls. The circadian maximum (acrophase) of plasma cortisol was similar in both groups, approximately 8.00 A.M., however, a statistically significant increase was found in the 24 hour-mean value (mesor) of infected patients as compared to healthy controls. Circadian rhythms were statistically validated in all lymphocyte subsets of healthy controls, whereas, large alterations were found in patients with acquired immunodeficiency syndrome (AIDS), already in asymptomatic infected individuals. The alterations concern the mesor and the amplitude for B and CD4 lymphocytes and all cycle parameters for CD3 and CD8 lymphocytes.
在13名感染HIV的男性和14名健康男性对照中研究了循环B和T（CD3、CD4、CD8）淋巴细胞亚群以及血浆皮质醇的昼夜节律。两组血浆皮质醇的昼夜最大值（峰值相位）相似，约为上午8点，然而，与健康对照相比，感染患者的24小时平均值（中值）有统计学意义的增加。健康对照的所有淋巴细胞亚群的昼夜节律均经统计学验证，而在获得性免疫缺陷综合征（AIDS）患者中，即使是无症状感染个体，也发现了较大改变。这些改变涉及B和CD4淋巴细胞的中值和振幅以及CD3和CD8淋巴细胞的所有周期参数。
