Hancock Pavla, Larner Andrew J
Brooker Centre , Runcorn , UK.
Int J Psychiatry Clin Pract. 2015 Mar;19(1):71-4. doi: 10.3109/13651501.2014.940056. Epub 2014 Jul 23.
Both dementia and depression may produce complaints of memory impairment. Differential diagnosis may be difficult, but has practical implications regarding the choice of appropriate treatment. The clinical utility of the Cornell Scale for Depression in Dementia (CSDD), a validated instrument for the diagnosis of depression in patients both with and without dementia, was assessed for the differentiation of patients with and without dementia who had been referred with complaints of memory impairment to a dedicated memory clinic.
Pragmatic prospective study of consecutive referrals with a suitable informant (n = 242) to a memory clinic, diagnosed using standard clinical diagnostic criteria for dementia (DSM-IV) and also administered the CSDD.
Using traditional parameters of diagnostic utility (sensitivity, specificity, positive predictive value, likelihood ratios) CSDD performance was good for the diagnosis of depression but only modest for the diagnosis of dementia.
CSDD proved useful as a brief screen for depression in patients attending a memory clinic with a complaint of memory impairment.
痴呆和抑郁症均可引发记忆障碍的主诉。鉴别诊断可能存在困难，但对于选择合适的治疗方法具有实际意义。康奈尔痴呆抑郁量表（CSDD）是一种经过验证的工具，可用于诊断患有或未患有痴呆症的患者的抑郁症，本研究评估了该量表在区分因记忆障碍主诉而被转诊至专门记忆门诊的痴呆患者和非痴呆患者方面的临床效用。
对连续转诊至记忆门诊且有合适 informant（n = 242）的患者进行实用前瞻性研究，采用痴呆症的标准临床诊断标准（DSM-IV）进行诊断，并使用 CSDD。
使用传统的诊断效用参数（敏感性、特异性、阳性预测值、似然比），CSDD 在抑郁症诊断方面表现良好，但在痴呆症诊断方面表现一般。
对于因记忆障碍主诉而就诊于记忆门诊的患者，CSDD 被证明是一种有用的抑郁症简易筛查工具。
