Payami H, Joe S, Thomson G
Department of Medical Genetics L-103, Oregon Health Sciences University, Portland 97201.
Genet Epidemiol. 1989;6(1):137-41. doi: 10.1002/gepi.1370060126.
The prevalence rate for autoimmune thyroid disease (ATD) is about 30 times higher in the type I diabetic (IDDM) families that were ascertained for Genetic Analysis Workshop 5 (GAW5) than in the general population. Two approaches were used to study the clustering of ATD and IDDM in these families: 1) HLA haplotype sharing in sib pairs in which one has IDDM and the other has ATD was analyzed with the genetic interrelationship method. The hypotheses of different alleles (at the same locus or at different loci) were rejected. Thus there must exist at least one common allele that predisposes to both IDDM and ATD. 2) The DR genotype frequencies suggest that in the GAW5 families two alleles may be predisposing to ATD; a recessive DR3-associated allele and a dominant DR4-associated allele.
在为遗传分析研讨会5（GAW5）确定的1型糖尿病（IDDM）家族中，自身免疫性甲状腺疾病（ATD）的患病率比普通人群高约30倍。采用了两种方法来研究这些家族中ATD和IDDM的聚集情况：1）使用遗传相关性方法分析了一个患有IDDM而另一个患有ATD的同胞对中的HLA单倍型共享情况。不同等位基因（在同一基因座或不同基因座）的假设被否定。因此，必然存在至少一个使个体易患IDDM和ATD的共同等位基因。2）DR基因型频率表明，在GAW5家族中，可能有两个等位基因使个体易患ATD；一个与DR3相关的隐性等位基因和一个与DR4相关的显性等位基因。
