Risch N
Department of Epidemiology, Yale University School of Medicine, New Haven, Connecticut 06510.
Genet Epidemiol. 1989;6(1):143-8. doi: 10.1002/gepi.1370060127.
Analysis of the Fifth Genetic Analysis Workshop (GAW5) insulin-dependent diabetes mellitus (IDDM) data leads to the following conclusions: 1) With a maximum-likelihood affected sib pair method, there is strong evidence for linkage with HLA and no evidence for linkage with INS, Gm, or Km. 2) Susceptibility as defined by HLA genotypes is very complex. Each DR allele has a unique susceptibility, and DR3 and DR4 haplotype associations for DR 3/4 genotypes are different from those for 3/X and 4/X. 3) Risk is substantially higher in sibships with an affected father compared to those with an affected mother. This excess cannot be attributed to transmission distortion at HLA.
对第五届遗传分析研讨会（GAW5）的胰岛素依赖型糖尿病（IDDM）数据进行分析后得出以下结论：1）采用最大似然法分析患病同胞对数据，有充分证据表明与HLA存在连锁关系，而没有证据表明与INS、Gm或Km存在连锁关系。2）由HLA基因型定义的易感性非常复杂。每个DR等位基因都有独特的易感性，DR3/4基因型中DR3和DR4单倍型的关联与3/X和4/X基因型中的不同。3）与母亲患病的同胞相比，父亲患病的同胞患IDDM的风险要高得多。这种差异不能归因于HLA的传递扭曲。
