Mondello Stefania, Cantrell Amy, Italiano Domenico, Fodale Vincenzo, Mondello Patrizia, Ang Darwin
Department of Neurosciences, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
Department of Biostatistics, College of Public Health and Health Professions, College of Medicine, University of Florida, P.O. Box 117450, 2004 Mowry Road, 5th Floor CTRB, Gainesville, FL 32611-7450, USA.
Biomed Res Int. 2014;2014:473419. doi: 10.1155/2014/473419. Epub 2014 Jun 3.
The aims of this study were to evaluate the complications that occur after trauma and the characteristics of individuals who develop complications, to identify potential risk factors that increase their incidence, and finally to investigate the relationship between complications and mortality.
We did a population-based retrospective study of trauma patients admitted to ICUs of a level I trauma center. Logistic regression analyses were performed to determine independent predictors for complications.
Of the 11,064 patients studied, 3,451 trauma patients developed complications (31.2%). Complications occurred significantly more in younger male patients. Length of stay was correlated with the number of complications (R = 0.435, P < 0.0001). The overall death rate did not differ between patients with or without complications. The adjusted odds ratio (OR) of developing complication for patients over age 75 versus young adults was 0.7 (P < 0.0001). Among males, traumatic central nervous system (CNS) injury was an important predictor for complications (adjusted OR 1.24).
Complications after trauma were found to be associated with age, gender, and traumatic CNS injury. Although these are not modifiable factors, they may identify subjects at high risk for the development of complications, allowing for preemptive strategies for prevention.
本研究旨在评估创伤后发生的并发症以及发生并发症的个体特征,识别增加其发生率的潜在风险因素,并最终研究并发症与死亡率之间的关系。
我们对一家一级创伤中心重症监护病房收治的创伤患者进行了一项基于人群的回顾性研究。进行逻辑回归分析以确定并发症的独立预测因素。
在研究的11064例患者中,3451例创伤患者发生了并发症(31.2%)。并发症在年轻男性患者中显著更多见。住院时间与并发症数量相关(R = 0.435,P < 0.0001)。有并发症和无并发症患者的总体死亡率无差异。75岁以上患者与年轻成年人相比发生并发症的校正比值比(OR)为0.7(P < 0.0001)。在男性中,创伤性中枢神经系统(CNS)损伤是并发症的重要预测因素(校正OR 1.24)。
发现创伤后并发症与年龄、性别和创伤性CNS损伤有关。虽然这些不是可改变的因素,但它们可能识别出发生并发症的高风险受试者,从而制定预防的抢先策略。