新型活载体重组伪狂犬病病毒疫苗的研究概况。
An overview of live attenuated recombinant pseudorabies viruses for use as novel vaccines.
机构信息
Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Xiangfang District, Harbin 150030, China.
Animal Parasitic Diseases Laboratory, Agricultural Research Service, Beltsville, MD 20705, USA.
出版信息
J Immunol Res. 2014;2014:824630. doi: 10.1155/2014/824630. Epub 2014 Jun 5.
Pseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. PRV has many nonessential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation. Recombinant PRVs expressing both native and foreign antigens are able to stimulate immune responses. In this paper, we review the current status of live attenuated recombinant PRVs and live PRV-based vector vaccines with potential for controlling viral infections in animals.
伪狂犬病病毒（PRV）是一种双链、DNA 基的猪病毒，其基因组大小约为 150kb。PRV 有许多非必需基因，这些基因可以被编码异源抗原的基因所取代，而不会对病毒的繁殖产生有害影响。表达天然和外来抗原的重组 PRV 能够刺激免疫反应。本文综述了目前用于控制动物病毒感染的减毒活重组 PRV 和基于活 PRV 的载体疫苗的现状。
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