Knook D L, Brouwer A
TNO Institute for Experimental Gerontology, Rijswijk, The Netherlands.
Immunol Invest. 1989 Jan-May;18(1-4):339-50. doi: 10.3109/08820138909112247.
Aging is associated with a significant increase in the susceptibility to scepsis and endotoxin induced shock in both man and experimental animals. In this study, some metabolic, heamodynamic and other pathophysiological factors possibly involved in the increased mortality of aged rats after endotoxin administration were investigated. The results indicate that older rats display an overall decrease in the capacity to maintain homeostasis after endotoxin challenge, which is expressed by severe disregulation of body temperature (hypothermia), glucose metabolism (hypoglycemia), tissue perfusion (fibrinolytic and anti-fibrinolytic factors) and severe tissue damage. Although a slight decrease in the clearance of endotoxin from the circulation was noted in old rats, alterations in the secondary response, evoked by stimulated macrophages and other cells appear to be more important in the age-related increase in susceptibility.
衰老与人类和实验动物对脓毒症及内毒素诱导性休克的易感性显著增加有关。在本研究中，对一些可能与内毒素给药后老年大鼠死亡率增加有关的代谢、血流动力学及其他病理生理因素进行了调查。结果表明，老年大鼠在内毒素攻击后维持体内平衡的能力总体下降，表现为体温（体温过低）、葡萄糖代谢（低血糖）、组织灌注（纤溶和抗纤溶因子）严重失调以及严重的组织损伤。尽管老年大鼠循环中内毒素清除率略有下降，但刺激巨噬细胞和其他细胞引发的二次反应改变在与年龄相关的易感性增加中似乎更为重要。
