库普弗细胞和内毒素敏感性的物种差异。
Species differences in Kupffer cells and endotoxin sensitivity.
作者信息
McCuskey R S, McCuskey P A, Urbaschek R, Urbaschek B
出版信息
Infect Immun. 1984 Jul;45(1):278-80. doi: 10.1128/iai.45.1.278-280.1984.
Abstract
The relative species sensitivity to Escherichia coli O111:B4 endotoxin was found to be guinea pig greater than hamster greater than mouse greater than rat. The 50% lethal dose of this endotoxin correlated with both the rate at which single latex particles were phagocytosed by individual Kupffer cells and the number of Kupffer cells in hepatic lobules that phagocytosed latex. The results suggests that the intrahepatic density and the level of activation of Kupffer cells participate in determining endotoxin sensitivity.
摘要
已发现对大肠杆菌O111:B4内毒素的相对物种敏感性为豚鼠大于仓鼠大于小鼠大于大鼠。这种内毒素的50%致死剂量与单个库普弗细胞吞噬单个乳胶颗粒的速率以及肝小叶中吞噬乳胶的库普弗细胞数量均相关。结果表明，肝内库普弗细胞的密度和活化水平参与了内毒素敏感性的决定。
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