干细胞的免疫调节与再生
Immune modulation of stem cells and regeneration.
作者信息
Aurora Arin B, Olson Eric N
机构信息
Department of Molecular Biology and Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
Department of Molecular Biology and Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
出版信息
Cell Stem Cell. 2014 Jul 3;15(1):14-25. doi: 10.1016/j.stem.2014.06.009.
Abstract
The immune system, best known as the first line of defense against invading pathogens, is integral to tissue development, homeostasis, and wound repair. In recent years, there has been a growing appreciation that cellular and humoral components of the immune system also contribute to regeneration of damaged tissues, including limbs, skeletal muscle, heart, and the nervous system. Here, we discuss key findings that implicate inflammatory cells and their secreted factors in tissue replacement after injury via stem cells and other reparative mechanisms. We highlight clinical conditions that are amenable to immune-mediated regeneration and suggest immune targeting strategies for tissue regeneration.
摘要
免疫系统作为抵御入侵病原体的第一道防线广为人知，它对于组织发育、内环境稳定和伤口修复至关重要。近年来，人们越来越认识到免疫系统的细胞和体液成分也有助于受损组织的再生，包括肢体、骨骼肌、心脏和神经系统。在此，我们讨论了一些关键发现，这些发现表明炎症细胞及其分泌因子通过干细胞和其他修复机制参与损伤后组织的替代。我们强调了适合免疫介导再生的临床情况，并提出了组织再生的免疫靶向策略。
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