Docherty Anna R, Sponheim Scott R, Kerns John G
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23220 USA.
Psychology Service, Minneapolis Veterans Affairs Health Care System, Minneapolis, MN 55417 USA; Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455 USA.
Schizophr Res. 2014 Sep;158(1-3):261-3. doi: 10.1016/j.schres.2014.06.015. Epub 2014 Jul 2.
It remains unclear whether ambivalence reflects genetic liability for schizophrenia-spectrum disorders. This study examined whether task-measured ambivalence is 1) increased in schizophrenia/schizoaffective disorder, 2) significantly associated with schizophrenia symptoms, and/or 3) increased in first-degree biological relatives of probands. Consistent with previous research, ambivalence was elevated in schizophrenia/schizoaffective probands and significantly related to current emotional state, but not to symptoms. Ambivalence was not elevated in relatives, suggesting that it may be unrelated to genetic liability. These results suggest that emotional state may differentially influences ambivalence across groups. Future research would benefit from examination of this question in a larger cohort.
矛盾情绪是否反映精神分裂症谱系障碍的遗传易感性仍不清楚。本研究调查了通过任务测量的矛盾情绪是否：1）在精神分裂症/分裂情感性障碍中增加；2）与精神分裂症症状显著相关；和/或3）在先证者的一级生物学亲属中增加。与先前的研究一致，矛盾情绪在精神分裂症/分裂情感性障碍先证者中升高，且与当前情绪状态显著相关，但与症状无关。亲属中的矛盾情绪没有升高，这表明它可能与遗传易感性无关。这些结果表明，情绪状态可能对不同群体的矛盾情绪产生不同影响。未来的研究若在更大的队列中考察这个问题将有所助益。
