孤立性惠尔普氏心内膜炎：一种被低估的诊断，需要对手术材料进行分子分析。
Isolated Whipple's endocarditis: an underestimated diagnosis that requires molecular analysis of surgical material.
机构信息
Institute of Pathology, University of Ulm, Ulm, Germany; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Department of Cardiac and Thoracic Surgery, University of Ulm, Ulm, Germany.
出版信息
Ann Thorac Surg. 2014 Jul;98(1):e1-3. doi: 10.1016/j.athoracsur.2014.04.059.
Tropheryma whipplei is known as the bacterium that causes Whipple's disease, a rare systemic illness typically affecting gastrointestinal tract, joints, and central nervous system. In addition, T whipplei infection may present as an isolated endocarditis. Although previously regarded as a rare condition, T whipplei has been recognized as a major cause of culture-negative endocarditis when integrating specific molecular analysis of surgical material into the diagnostic algorithm. Here, we report the case of a 67-year-old man undergoing mitral valve replacement due to T whipplei endocarditis, and discuss diagnostic and therapeutic implications.
特罗斐姆菌（Tropheryma whipplei）被称为导致惠普尔病（Whipple's disease）的细菌，这是一种罕见的全身性疾病，通常影响胃肠道、关节和中枢神经系统。此外，特罗斐姆菌感染也可能表现为孤立性心内膜炎。尽管以前被认为是一种罕见疾病，但当将手术标本的特定分子分析纳入诊断算法时，特罗斐姆菌已被认为是导致培养阴性心内膜炎的主要原因。在这里，我们报告了一例因特罗斐姆菌心内膜炎而行二尖瓣置换术的 67 岁男性患者，并讨论了诊断和治疗的意义。
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