Kiyosawa K, Sodeyama T, Akahane Y, Gibo Y, Tanaka E, Nakano Y, Furuta S
Nihon Shokakibyo Gakkai Zasshi. 1989 Jan;86(1):32-8.
The aim of this study is to evaluate the risk of infection of non-A, non-B acute hepatitis (NANB-AH) in hospital employees. Among 593 patients with acute viral hepatitis (AVH), hospital employees were 3/147 (2%) in type A, 19/174 (11%) in type B and 21/272 (8%) in non-A, non-B (NANB). All 43 patients were medical staffs such as doctors, nurses and laboratory technicians. Out of 21 patients with NANB hepatitis of hospital employees, 7 were doctors, 14 nurses and 6 laboratory technicians. Eight of them had preceding accidental needlestick exposures. Out of 17,290 employees of our hospital during 18 years, 27 medical persons developed AVH. They were 2 hepatitis A, 10 hepatitis B and 15 hepatitis NANB. No non-medical staff developed AVH. Out of 15 NANB hepatitis patients, 7 had needlestick accidents 4 to 6 weeks before development of the illness, and all donor patients showed liver diseases. During 3 years (1985 to 1987), there were 116 needlestick accidents in our hospital which happened in medical staffs alone, and 50 of them were NANB hepatitis-related accidents. Three ml of human immune serum globulin (ISG) was administered intramuscurally just after accidents to 23 persons but not to 27 persons. NANB hepatitis were developed in 2 doctors who were not treated with ISG. In conclusion, NANB hepatitis occurred in hospital employees especially in medical staffs.
本研究旨在评估医院工作人员感染非甲非乙型急性肝炎（NANB - AH）的风险。在593例急性病毒性肝炎（AVH）患者中，医院工作人员中甲型肝炎为3/147（2%），乙型肝炎为19/174（11%），非甲非乙型（NANB）为21/272（8%）。所有43例患者均为医生、护士和实验室技术人员等医务人员。在21例医院工作人员的NANB型肝炎患者中，7例为医生，14例为护士，6例为实验室技术人员。其中8例之前有意外针刺暴露史。在我院18年间的17290名员工中，27名医务人员发生了AVH。其中甲型肝炎2例，乙型肝炎10例，NANB型肝炎15例。非医务人员未发生AVH。在15例NANB型肝炎患者中，7例在发病前4至6周有针刺事故，且所有供血者患者均有肝脏疾病。在3年（1985年至1987年）期间，我院仅医务人员就发生了116起针刺事故，其中50起与NANB型肝炎相关。事故发生后，23人立即肌肉注射了3毫升人免疫血清球蛋白（ISG），27人未注射。未接受ISG治疗的2名医生发生了NANB型肝炎。总之，NANB型肝炎发生在医院工作人员中，尤其是医务人员。
