Setoguchi Y, Yamamoto K, Ozaki I, Fujio N, Kariya T, Sakai T, Fujii S
Department of Internal Medicine, Saga Medical School, Japan.
Gastroenterol Jpn. 1991 Apr;26(2):157-61. doi: 10.1007/BF02811074.
The authors examined the contribution of Hepatitis C Virus (HCV) to the morbidity of chronic liver diseases (CLD) in selected districts of Saga, Japan, one group with low (L) and the other with a high (H) mortality rate of CLD. Age and sex-matched epidemiological studies showed an extremely high morbidity of CLD in the H-district (5.3%) and a low one in the L-districts (2.1%). Randomized selected studies of anti-HCV antibodies showed an extremely high frequency of 10.8% in the H-district and a frequency of 4.6% in the L-district. In addition, the number of subjects with both CLD and positive anti-HCV antibodies was significantly higher in subjects older than the fifth decade, in the H-district. The high prevalence of HCV may be related to the high morbidity and mortality rate of CLD in these districts of Japan.
作者研究了丙型肝炎病毒（HCV）对日本佐贺县选定地区慢性肝病（CLD）发病的影响，其中一组CLD死亡率低（L），另一组CLD死亡率高（H）。年龄和性别匹配的流行病学研究表明，H区CLD发病率极高（5.3%），L区发病率较低（2.1%）。抗HCV抗体的随机抽样研究显示，H区的频率极高，为10.8%，L区为4.6%。此外，在H区，年龄超过五十岁且同时患有CLD和抗HCV抗体呈阳性的受试者数量明显更多。HCV的高流行率可能与日本这些地区CLD的高发病率和高死亡率有关。
