分娩非同卵双胞胎。
Delivering nonidentical twins.
机构信息
Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA.
出版信息
Nat Struct Mol Biol. 2014 Aug;21(8):649-51. doi: 10.1038/nsmb.2852. Epub 2014 Jul 6.
Abstract
Two sibling DNA polymerases synthesize most of the eukaryotic nuclear genome. A new study provides insights into the distinct protein interactions that deliver these replicases for asymmetric leading- and lagging-strand replication and reveals possible cross-talk between DNA replication and other cellular processes.
摘要
两种亲族 DNA 聚合酶合成了大部分真核生物核基因组。一项新研究深入了解了独特的蛋白质相互作用，这些相互作用将这些复制酶递送到不对称的前导链和滞后链复制中，并揭示了 DNA 复制与其他细胞过程之间可能存在的交叉对话。
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本文引用的文献
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Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork.真核复制叉处不对称聚合酶组装的机制。
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DNA damage tolerance: a double-edged sword guarding the genome.DNA损伤耐受：守护基因组的双刃剑。
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The minichromosome maintenance replicative helicase.微小染色体维持复制解旋酶
Cold Spring Harb Perspect Biol. 2013 Nov 1;5(11):a012807. doi: 10.1101/cshperspect.a012807.
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Principles and concepts of DNA replication in bacteria, archaea, and eukarya.原核生物、古菌和真核生物中 DNA 复制的原理和概念。
Cold Spring Harb Perspect Biol. 2013 Jul 1;5(7):a010108. doi: 10.1101/cshperspect.a010108.
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Chromatin and DNA replication.染色质与 DNA 复制。
Cold Spring Harb Perspect Biol. 2013 Aug 1;5(8):a010207. doi: 10.1101/cshperspect.a010207.
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Replicative DNA polymerases.复制 DNA 聚合酶。
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