DNA中的核糖核苷酸：起源、修复及后果
Ribonucleotides in DNA: origins, repair and consequences.
作者信息
Williams Jessica S, Kunkel Thomas A
机构信息
Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States.
Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States.
出版信息
DNA Repair (Amst). 2014 Jul;19:27-37. doi: 10.1016/j.dnarep.2014.03.029. Epub 2014 Apr 30.
Abstract
While primordial life is thought to have been RNA-based (Cech, Cold Spring Harbor Perspect. Biol. 4 (2012) a006742), all living organisms store genetic information in DNA, which is chemically more stable. Distinctions between the RNA and DNA worlds and our views of "DNA" synthesis continue to evolve as new details emerge on the incorporation, repair and biological effects of ribonucleotides in DNA genomes of organisms from bacteria through humans.
摘要
虽然原始生命被认为是以RNA为基础的（切赫，《冷泉港生物学展望》4 (2012) a006742），但所有生物都将遗传信息存储在化学性质更稳定的DNA中。随着从细菌到人类等生物体DNA基因组中核糖核苷酸的掺入、修复及生物学效应的新细节不断涌现，RNA世界和DNA世界之间的区别以及我们对“DNA”合成的看法也在持续演变。
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