普拉德氟沙星：一种用于治疗猫细菌感染的新型兽用氟喹诺酮类药物。
Pradofloxacin: a novel veterinary fluoroquinolone for treatment of bacterial infections in cats.
作者信息
Sykes Jane E, Blondeau Joseph M
机构信息
Department of Medicine and Epidemiology, 2108 Tupper Hall, University of California, Davis, Davis, CA 95616, USA.
Departments of Pathology and Laboratory Medicine, Microbiology and Immunology and Ophthalmology, Royal University Hospital, Saskatoon Health Region and University of Saskatchewan, Saskatoon, Saskatchewan S7N 0W8, Canada.
出版信息
Vet J. 2014 Aug;201(2):207-14. doi: 10.1016/j.tvjl.2014.06.008. Epub 2014 Jun 10.
Pradofloxacin is a novel third-generation oral veterinary fluoroquinolone with activity against Gram-positive aerobic bacteria and anaerobes (lower minimum inhibitory concentrations in vitro). It also has activity against other bacterial species, including Bartonella henselae, Pasteurella multocida, Bordetella bronchiseptica, extra-intestinal Escherichia coli, and some mycobacterial species. This review focuses on the current knowledge of the mechanism of action, adverse effects, clinical applications, and pharmacokinetic/pharmacodynamic properties of pradofloxacin in cats.
普拉德氟沙星是一种新型的第三代口服兽用氟喹诺酮类药物，对革兰氏阳性需氧菌和厌氧菌具有活性（体外最低抑菌浓度较低）。它对其他细菌种类也有活性，包括汉赛巴尔通体、多杀巴斯德菌、支气管败血波氏杆菌、肠道外大肠杆菌以及一些分枝杆菌种类。本综述聚焦于普拉德氟沙星在猫体内的作用机制、不良反应、临床应用以及药代动力学/药效学特性的现有知识。
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