Lee Mary Ann, Woerde Dennis J, Reagan Krystle L, Wolf Tatiana G, Sykes Jane E
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, CA, USA.
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, CA, USA.
JFMS Open Rep. 2025 Jan 19;11(1):20551169241298058. doi: 10.1177/20551169241298058. eCollection 2025 Jan-Jun.
A 9-year-old male castrated domestic shorthair cat from northern California was evaluated for a 12-month history of dermal and subcutaneous dermatitis in the inguinal region. Histopathologic examination of a biopsy revealed severe, chronic, multifocal to coalescing pyogranulomatous dermatitis and panniculitis, accompanied by ulceration and central necrosis. Aerobic bacterial culture of lesions yielded mycobacterial growth. Empiric antimicrobial therapy was initiated with doxycycline and marbofloxacin pending culture and susceptibility. Culture of a biopsy followed by gene sequencing at a mycobacterial reference laboratory yielded after 6 weeks. Ten months after initial antimicrobial administration, the lesions resolved.
To date, in cats, panniculitis has been reported from Ohio, Massachusetts and British Columbia in North America; two additional cases were reported from southeastern Australia. In humans, infections have been reported from several states in the USA, predominantly in the Midwest and coastal south, but not from the west. This report extends the known spatial distribution of to the western USA and strengthens its association with panniculitis in cats. It also demonstrates the need for prolonged incubation for diagnosis of some rapidly growing mycobacteria infections using culture.
一只来自加利福尼亚州北部的9岁去势家养短毛雄性猫，因腹股沟区域皮肤和皮下皮炎长达12个月的病史接受评估。活检的组织病理学检查显示严重的慢性多灶性至融合性脓性肉芽肿性皮炎和脂膜炎，并伴有溃疡和中央坏死。病变的需氧菌培养产生分枝杆菌生长。在培养和药敏试验结果出来之前，开始使用强力霉素和马波沙星进行经验性抗菌治疗。活检组织培养后，在一家分枝杆菌参考实验室进行基因测序，6周后得出结果。首次给予抗菌药物10个月后，病变消退。
迄今为止，在猫身上，脂膜炎已在北美俄亥俄州、马萨诸塞州和不列颠哥伦比亚省有报道；澳大利亚东南部又报告了另外两例。在人类中，美国几个州都报告了感染病例，主要在中西部和南部沿海地区，但西部没有。本报告将已知的感染空间分布扩展到美国西部，并加强了其与猫脂膜炎的关联。它还表明，使用培养方法诊断一些快速生长的分枝杆菌感染需要较长的培养时间。
