Bichara David A, Malchau Erik, Sillesen Nanna H, Cakmak Selami, Nielsen G Petur, Muratoglu Orhun K
Harris Orthopaedic Laboratory, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
Harris Orthopaedic Laboratory, Massachusetts General Hospital, Boston, Massachusetts.
J Arthroplasty. 2014 Sep;29(9 Suppl):232-7. doi: 10.1016/j.arth.2014.03.044. Epub 2014 May 24.
Recent in vitro findings suggest that UHMWPE wear particles containing vitamin E (VE) may have reduced biologic activity and decreased osteolytic potential. We hypothesized that particles from VE-stabilized, radiation cross-linked UHMWPE would cause less osteolysis in a murine calvarial bone model when compared to virgin gamma irradiated cross-linked UHMWPE. Groups received equal amount of particulate debris overlaying the calvarium for 10 days. Calvarial bone was examined using high resolution micro-CT and histomorphometric analyses. There was a statistically significant difference between virgin (12.2%±8%) and VE-UHMWPE (3%±1.4%) groups in regards to bone resorption (P=0.005) and inflammatory fibrous tissue overlaying the calvaria (0.48 vs. 0.20, P<0.0001). These results suggest that VE-UHMWPE particles have reduced osteolytic potential in vivo when compared to virgin UHMWPE.
最近的体外研究结果表明，含有维生素E（VE）的超高分子量聚乙烯（UHMWPE）磨损颗粒可能具有降低的生物活性和溶骨潜能。我们假设，与原始γ辐照交联的UHMWPE相比，来自VE稳定化、辐射交联的UHMWPE的颗粒在小鼠颅骨模型中引起的骨溶解更少。各实验组在颅骨上覆盖等量的颗粒碎片，持续10天。使用高分辨率微型计算机断层扫描（micro-CT）和组织形态计量学分析对颅骨进行检查。在骨吸收方面，原始组（12.2%±8%）和VE-UHMWPE组（3%±1.4%）之间存在统计学显著差异（P=0.005），覆盖颅骨的炎性纤维组织方面也有差异（0.48对0.20，P<0.0001）。这些结果表明，与原始UHMWPE相比，VE-UHMWPE颗粒在体内具有更低的溶骨潜能。
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