Liu Tzu-Ming, Yu Jiashing, Chang C Allen, Chiou Arthur, Chiang Huihua Kenny, Chuang Yu-Chun, Wu Cheng-Han, Hsu Che-Hao, Chen Po-An, Huang Chih-Chia
1] Institute of Biomedical Engineering and Molecular Imaging Center, National Taiwan University, Taipei, 106, Taiwan [2].
1] Department of Chemical Engineering, National Taiwan University, Taipei, 106, Taiwan [2].
Sci Rep. 2014 Jul 7;4:5593. doi: 10.1038/srep05593.
Surface functionalized nanoparticles have found their applications in several fields including biophotonics, nanobiomedicine, biosensing, drug delivery, and catalysis. Quite often, the nanoparticle surfaces must be post-coated with organic or inorganic layers during the synthesis before use. This work reports a generally one-pot synthesis method for the preparation of various inorganic-organic core-shell nanostructures (Au@polymer, Ag@polymer, Cu@polymer, Fe3O4@polymer, and TiO2@polymer), which led to new optical, magnetic, and catalytic applications. This green synthesis involved reacting inorganic precursors and poly(styrene-alt-maleic acid). The polystyrene blocks separated from the external aqueous environment acting as a hydrophobic depot for aromatic drugs and thus illustrated the integration of functional nanoobjects for drug delivery. Among these nanocomposites, the Au@polymer nanoparticles with good biocompatibility exhibited shell-dependent signal enhancement in the surface plasmon resonance shift, nonlinear fluorescence, and surface-enhanced Raman scattering properties. These unique optical properties were used for dual-modality imaging on the delivery of the aromatic photosensitizer for photodynamic therapy to HeLa cells.
表面功能化纳米粒子已在包括生物光子学、纳米生物医学、生物传感、药物递送和催化等多个领域得到应用。在使用前的合成过程中，纳米粒子表面常常必须用有机或无机层进行后包覆。本文报道了一种通用的一锅法合成方法，用于制备各种无机-有机核壳纳米结构（金@聚合物、银@聚合物、铜@聚合物、四氧化三铁@聚合物和二氧化钛@聚合物），这带来了新的光学、磁性和催化应用。这种绿色合成方法涉及无机前驱体与聚（苯乙烯-alt-马来酸）的反应。聚苯乙烯嵌段与外部水环境分离，作为芳香族药物的疏水储存库，从而展示了用于药物递送的功能性纳米物体的整合。在这些纳米复合材料中，具有良好生物相容性的金@聚合物纳米粒子在表面等离子体共振位移、非线性荧光和表面增强拉曼散射特性方面表现出壳层依赖性信号增强。这些独特的光学性质被用于对芳香族光敏剂向HeLa细胞递送进行光动力治疗时的双模态成像。
