Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, USA; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA; College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA.
Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA.
J Control Release. 2014 Sep 28;190:75-81. doi: 10.1016/j.jconrel.2014.06.041. Epub 2014 Jul 4.
In this review we present some of the seminal contributions that have established the mathematical foundations of controlled drug delivery and led to the modern models. Mathematical modeling is no longer just a dry exercise in generating more and more complex models or a parametric fitting process, but rather an advanced analysis that can lead to a priori examination of a release/delivery process or a series of design equations that help the practitioner achieve a better formulation.
在这篇综述中，我们介绍了一些开创性的贡献，这些贡献为控制药物释放奠定了数学基础，并导致了现代模型的出现。数学建模不再仅仅是生成越来越复杂的模型或参数拟合过程的枯燥练习，而是一种高级分析，可以帮助预先检查释放/输送过程或一系列有助于实践者设计更好配方的设计方程。
