洋甘菊对百草枯诱导的大鼠肺氧化损伤的改善作用。
Ameliorative effect of Matricaria chamomilla .L on paraquat: Induced oxidative damage in lung rats.
作者信息
Ranjbar Akram, Mohsenzadeh Fariba, Chehregani Abdolkarim, Khajavi Farzad, Zijoud Seyed-Mostafa Hossini, Ghasemi Hassan
机构信息
Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Biology, Laboratory of Plant Cell Biology, Bu-Ali Sina University, Hamadan, Iran.
出版信息
Pharmacognosy Res. 2014 Jul;6(3):199-203. doi: 10.4103/0974-8490.132595.
BACKGROUND
Herbal medicines have been long used for antioxidant properties. The purpose of this study was to investigate the effect of hydroalcholic extract Matricaria chamomilla. L (M. chamomilla) against Paraquat (PQ) induced pulmonary injury in association with its antioxidant activity.
MATERIALS AND METHODS
Effective doses of PQ (5 mg/kg/day) and M. chamomilla (50 mg/kg/day) were administered alone or in combination for 7 days. At the end of the experiment, lung tissue of the animals was separated. The activity of enzymatic scavengers such as glutathione peroxidase (GPx) and superoxide dismutase (SOD), lipid peroxidation (LPO) and total antioxidant power (TAP) were measured.
RESULTS
In these samples, the LPO, SOD, and GPx were higher in the PQ group as compared with controls. M. chamomilla extract ameliorated LPO, SOD, GPx and increased TAP in plasma and lung tissue of PQ induced changes. Co administration of PQ with M. chamomilla improved LPO and SOD, and GPx.
CONCLUSION
M. chamomilla as natural antioxidant may be considered beneficial for the protection oxidative lung injury in PQ poisoning.
背景
草药长期以来因其抗氧化特性而被使用。本研究的目的是研究洋甘菊水醇提取物对百草枯（PQ）诱导的肺损伤的影响及其抗氧化活性。
材料与方法
单独或联合给予有效剂量的PQ（5毫克/千克/天）和洋甘菊（50毫克/千克/天），持续7天。实验结束时，分离动物的肺组织。测量谷胱甘肽过氧化物酶（GPx）和超氧化物歧化酶（SOD）等酶促清除剂的活性、脂质过氧化（LPO）和总抗氧化能力（TAP）。
结果
在这些样本中，与对照组相比，PQ组的LPO、SOD和GPx更高。洋甘菊提取物改善了PQ诱导的血浆和肺组织中LPO、SOD、GPx的变化，并增加了TAP。PQ与洋甘菊联合给药改善了LPO、SOD和GPx。
结论
洋甘菊作为天然抗氧化剂，可能对保护PQ中毒引起的氧化肺损伤有益。
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