Ortolani Emanuela, Guerriero Massimiliano, Coli Antonella, Di Giannuario Amalia, Minniti Gianluca, Polimeni Antonella
General Dentistry and Emergency Care Unit George Eastman Dental Hospital, Rome, Italy.
Laboratory of Pathology, A. Cardarelli Hospital, Campobasso, Italy.
Ann Stomatol (Roma). 2014 Jun 18;5(2):66-8. eCollection 2014 Apr.
The ability of platelet-derived growth factor (PDGF), insulin-like growth factor-1 (IGF-1) and platelet-rich plasma (PRP) to increase the rate of osseointegration of endosseous implants and to improve the quality of bone remodeling on the surface of titanium, has been investigated in an experimental intraosseous defect model by an histological and immunohistochemical evaluation. The results from this study demonstrate that rabbits treated with the combination PDGF/IGF-1 showed a higher positive effect on bone regeneration than PRP-treated or controls.
通过组织学和免疫组织化学评估，在实验性骨内缺损模型中研究了血小板衍生生长因子（PDGF）、胰岛素样生长因子-1（IGF-1）和富血小板血浆（PRP）提高骨内种植体骨结合率以及改善钛表面骨重塑质量的能力。本研究结果表明，联合使用PDGF/IGF-1治疗的兔子在骨再生方面比PRP治疗组或对照组显示出更高的积极效果。
