Allam Mohamed, Riad Hassan
Dermatology Department, Hamad Medical Corporation, Doha, Qatar.
Dermatology Department, Rumailah Hospital, Hamad Medical Corporation, Doha, Qatar.
Qatar Med J. 2013 Dec 23;2013(2):1-19. doi: 10.5339/qmj.2013.10. eCollection 2013.
Vitiligo is an acquired pigmentry disorder of the skin and mucous membranes which manifests as white macules and patches due to selective loss of melanocytes. Etiological hypotheses of vitiligo include genetic, immunological, neurohormonal, cytotoxic, biochemical, oxidative stress and newer theories of melanocytorrhagy and decreased melanocytes survival. There are several types of vitiligo which are usually diagnosed clinically and by using a Wood's lamp; also vitiligo may be associated with autoimmune diseases, audiological and ophthalmological findings or it can be a part of polyendocrinopathy syndromes. Several interventions are available for the treatment for vitiligo to stop disease progression and/or to attain repigmentation or even depigmentation. In this article, we will present an overall view of current standing of vitiligo research work especially in the etiological factors most notably the genetic components, also, types and associations and various and newer treatment modalities.
白癜风是一种获得性皮肤和黏膜色素沉着紊乱疾病，由于黑素细胞选择性缺失而表现为白色斑疹和斑块。白癜风的病因假说包括遗传、免疫、神经激素、细胞毒性、生化、氧化应激以及黑素细胞外渗和黑素细胞存活率降低等新理论。白癜风有几种类型，通常通过临床诊断和伍德灯检查来诊断；此外，白癜风可能与自身免疫性疾病、听力学和眼科检查结果相关，或者可能是多内分泌病综合征的一部分。有几种干预措施可用于白癜风的治疗，以阻止疾病进展和/或实现色素再生甚至色素脱失。在本文中，我们将全面介绍白癜风研究工作的现状，特别是病因因素，最显著的是遗传成分，以及类型、关联和各种新的治疗方式。
