Gangarapu Venkatanarayana, Yıldız Kemal, Ince Ali Tüzün, Baysal Birol
Department of Gastroenterology, Bezmialem Vakif University Faculty of Medicine, İstanbul, Turkey.
Turk J Gastroenterol. 2014 Apr;25(2):133-40. doi: 10.5152/tjg.2014.7886.
Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease in developed countries. Obesity is the most important risk factor for metabolic syndrome and NAFLD. Accumulated evidence has revealed that gut microbial compositional changes may be associated with more energy harvesting from the diet, which promotes increased fatty acid uptake from adipose tissue and shifts lipid metabolism from oxidation to de novo production. Furthermore, changes in intestinal barrier function contribute to metabolic endotoxemia in the form of low-grade microbial inflammation. Persistent inflammation exacerbates NAFLD progression. In this review, we discuss the role of gut microbiota in obesity and NAFLD.
非酒精性脂肪性肝病（NAFLD）是发达国家慢性肝病的主要病因。肥胖是代谢综合征和NAFLD最重要的危险因素。越来越多的证据表明，肠道微生物组成的变化可能与从饮食中获取更多能量有关，这会促进脂肪组织对脂肪酸摄取的增加，并使脂质代谢从氧化转变为从头合成。此外，肠道屏障功能的改变会导致以低度微生物炎症形式出现的代谢性内毒素血症。持续的炎症会加剧NAFLD的进展。在这篇综述中，我们讨论了肠道微生物群在肥胖和NAFLD中的作用。
