Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, Department of Medicine & Therapeutics and LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong.
Adv Exp Med Biol. 2018;1061:111-125. doi: 10.1007/978-981-10-8684-7_9.
Non-alcoholic fatty liver disease (NAFLD) is an increasingly important cause of chronic liver disease globally. Similar to metabolic syndrome and obesity, NAFLD is associated with alternations in the gut microbiota and its related biological pathways. While the exact pathophysiology of NAFLD remains largely unknown, changes in intestinal inflammation, gut permeability, energy harvest, anaerobic fermentation and insulin resistance have been described. In this chapter, we review the relationship between the gut microbiota, obesity and NAFLD, and highlight potential ways to modify the gut microbiota to help managing NAFLD patients.
非酒精性脂肪性肝病（NAFLD）是全球范围内慢性肝病日益重要的病因。与代谢综合征和肥胖症类似，NAFLD 与肠道微生物组及其相关生物学途径的改变有关。尽管 NAFLD 的确切病理生理学仍知之甚少，但肠道炎症、肠道通透性、能量获取、厌氧发酵和胰岛素抵抗的变化已被描述。在本章中，我们回顾了肠道微生物组、肥胖症和 NAFLD 之间的关系，并强调了改变肠道微生物组以帮助管理 NAFLD 患者的潜在方法。
