动态无序与信息转导的能量成本
Dynamic disorder and the energetic costs of information transduction.
作者信息
Thill Peter
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
出版信息
J Chem Phys. 2014 Jul 7;141(1):015102. doi: 10.1063/1.4885725.
Abstract
We study a model of dynamic disorder relevant for signal transduction pathways in which enzymatic reaction rates fluctuate over several orders of magnitude. For the simple networks we consider, dynamic disorder drives the system far from equilibrium and imposes an energetic burden for high fidelity signaling capability. We study how the dynamics of the underlying stochastic behavior in the reaction rate process is related to the energetic cost of transmitting information through the network.
摘要
我们研究了一个与信号转导通路相关的动态无序模型，其中酶促反应速率在几个数量级上波动。对于我们所考虑的简单网络，动态无序驱使系统远离平衡态，并对高保真信号传递能力施加了能量负担。我们研究了反应速率过程中潜在随机行为的动力学如何与通过网络传输信息的能量成本相关。
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