Jeria Sandhya, Thool Archana R, Daigavane Sachin, Ganjre Samyak
Department of Ophthalmology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Department of Dermatology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.
Cureus. 2022 Sep 26;14(9):e29600. doi: 10.7759/cureus.29600. eCollection 2022 Sep.
Gefitinib is a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It is used for treating locally advanced or metastatic non-small cell lung carcinoma and is well tolerated systemically. However, sight-threatening ocular adverse effects, like corneal ulcer and perforation, can occur due to the expression of EGFR on limbal and conjunctival epithelia. In this report, we describe a case of a 36-year-old female who presented with loss of eyebrow hair and eyelashes of both eyes and blurring of vision in the right eye. On ocular examination, the patient had anterior blepharitis, madarosis, punctuate epithelial erosions and reduced corneal sensation in both eyes, and corneal thinning in the right eye. On specular microscopy, there was decreased central corneal thickness in both eyes. Treatment with topical antibiotics and lubricating drops led to the resolution of blepharitis and punctate epithelial erosions. This case report aims to create awareness among ophthalmologists and oncologists about the early detection of gefitinib-related ocular adverse effects and timely intervention in patients.
吉非替尼是一种选择性表皮生长因子受体（EGFR）酪氨酸激酶抑制剂。它用于治疗局部晚期或转移性非小细胞肺癌，且全身耐受性良好。然而，由于EGFR在角膜缘和结膜上皮细胞上的表达，可能会出现威胁视力的眼部不良反应，如角膜溃疡和穿孔。在本报告中，我们描述了一例36岁女性病例，该患者出现双眼眉毛和睫毛脱落以及右眼视力模糊。眼部检查发现，患者双眼患有前部睑缘炎、睫毛脱落、点状上皮糜烂和角膜感觉减退，右眼角膜变薄。在角膜内皮显微镜检查中，双眼中央角膜厚度均降低。局部使用抗生素和润滑滴眼液治疗后，睑缘炎和点状上皮糜烂得到缓解。本病例报告旨在提高眼科医生和肿瘤学家对吉非替尼相关眼部不良反应的早期检测以及对患者及时进行干预的认识。
