Bwititi Phillip Taderera, Nwose Ezekiel Uba
School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, Australia.
School of Community Health, Charles Sturt University, Orange, Australia ; College of Health Sciences, Novena University, Ogume, Nigeria.
N Am J Med Sci. 2014 Jun;6(6):284-6. doi: 10.4103/1947-2714.134376.
The prevalence of prediabetes is increasing world-wide and this condition predisposes to substantially increased risk of cardiovascular disease in addition to developing diabetes mellitus (DM). This article debates screening for early identification and intervention of cardiovascular risk in prediabetes.
Screening methods exist for cardiovascular disease, but the models have diabetes and smoking status as dichotomous variables. A [Yes or No] response in regards to diabetes then ignores dysglycemia in prediabetes individuals who may nevertheless have hyperglycemia-induced oxidative stress. Therefore, the sufferers are treated like healthy persons in such screening models. The problem is worse especially in the low - mid income countries where diagnostic services are either inaccessible or unaffordable for comprehensive testing.
To improve early intervention of cardiovascular risk in subclinical diabetes, a model that employs a combination of blood glucose level and an index of oxidative damage is imperative to cater for prediabetes.
糖尿病前期在全球范围内的患病率正在上升，这种情况除了会发展为糖尿病（DM）外，还会使心血管疾病的风险大幅增加。本文探讨了对糖尿病前期进行心血管风险的早期识别和干预的筛查。
存在心血管疾病的筛查方法，但这些模型将糖尿病和吸烟状况作为二分变量。对于糖尿病的[是或否]回答忽略了糖尿病前期个体的血糖异常，而这些个体可能仍存在高血糖诱导的氧化应激。因此，在这种筛查模型中，患者被当作健康人对待。这个问题在中低收入国家尤为严重，在这些国家，诊断服务要么无法获得，要么进行全面检测的费用过高。
为了改善亚临床糖尿病患者心血管风险的早期干预，采用血糖水平和氧化损伤指标相结合的模型对于应对糖尿病前期至关重要。
