Jeffe Donna B, Andriole Dorothy A, Wathington Heather D, Tai Robert H
Dr. Jeffe is professor of medicine, Washington University School of Medicine, and director, Health Behavior, Communication, and Outreach Core, Alvin J. Siteman Cancer Center, Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, Missouri. Dr. Andriole is assistant dean for medical education and associate professor of surgery, Washington University School of Medicine, St. Louis, Missouri. Dr. Wathington is assistant professor, Curry School of Education, University of Virginia, Charlottesville, Virginia. Dr. Tai is associate professor, Curry School of Education, University of Virginia, Charlottesville, Virginia.
Acad Med. 2014 Oct;89(10):1398-407. doi: 10.1097/ACM.0000000000000400.
MD-PhD scientists are a successful, but small and fairly homogenous group of biomedical researchers. The authors conducted a retrospective cohort study to identify predictors of MD-PhD program enrollment to inform evidence-based strategies to increase the size and diversity of the biomedical research workforce.
Using deidentified data from all 2001-2006 Pre-Medical College Admission Test Questionnaire (PMQ) respondents, they developed multivariate logistic regression models to identify demographic, experiential, and attitudinal variables associated with MD-PhD program enrollment at matriculation compared with all other MD program enrollment at matriculation and with not enrolling in medical school by August 2012.
Of 207,436 PMQ respondents with complete data for all variables of interest, 2,575 (1.2%) were MD-PhD program enrollees, 80,856 (39.0%) were other MD program enrollees, and 124,005 (59.8%) were non-medical-school matriculants. Respondents who were black (versus white), were high school and college laboratory research apprenticeship participants, and highly endorsed the importance of research/finding cures as reasons to study medicine were more likely to be MD-PhD program enrollees, whereas respondents who highly endorsed the status of medicine as a reason to study medicine were less likely to be MD-PhD program enrollees than either other MD program enrollees or non-medical-school matriculants.
MD-PhD program directors succeed in enrolling students whose attitudes and interests align with MD-PhD program goals. Continued efforts are needed to promote MD-PhD workforce diversity and the value of high school and college research apprenticeships for students considering careers as physician-scientists.
医学博士-哲学博士（MD-PhD）科学家是一群成功的生物医学研究人员，但规模较小且同质化程度较高。作者进行了一项回顾性队列研究，以确定MD-PhD项目入学的预测因素，为基于证据的策略提供信息，以增加生物医学研究劳动力的规模和多样性。
利用2001 - 2006年所有医学院入学前考试问卷（PMQ）受访者的匿名数据，他们建立了多变量逻辑回归模型，以确定与入学时MD-PhD项目入学相关的人口统计学、经验和态度变量，与入学时所有其他MD项目入学情况以及截至2012年8月未进入医学院的情况进行比较。
在207,436名拥有所有感兴趣变量完整数据的PMQ受访者中，2,575人（1.2%）是MD-PhD项目的录取者，80,856人（39.0%）是其他MD项目的录取者，124,005人（59.8%）是未进入医学院的学生。黑人（与白人相比）、曾参与高中和大学实验室研究学徒项目的受访者，以及高度认可研究/寻找治愈方法作为学医理由的受访者更有可能成为MD-PhD项目的录取者，而高度认可医学地位作为学医理由的受访者成为MD-PhD项目录取者的可能性低于其他MD项目录取者或未进入医学院的学生。
MD-PhD项目主任成功录取了态度和兴趣与MD-PhD项目目标一致的学生。需要持续努力来促进MD-PhD劳动力的多样性，以及高中和大学研究学徒项目对考虑从事医师科学家职业的学生的价值。
