首发精神病患者的脑电图异常与 5 年预后。
Electroencephalographic abnormalities and 5-year outcome in first-episode psychosis.
机构信息
Director-Prevention and Early Intervention Program for Psychoses (PEPP), London Health Sciences Centre-Victoria Hospital, London, Ontario; Professor of Psychiatry, The University of Western Ontario, London, Ontario.
Professor, Departments of Psychiatry, and Epidemiology and Biostatistics, The University of Western Ontario, London, Ontario; Research Psychologist- PEPP, London Health Sciences Centre, London, Ontario.
出版信息
Can J Psychiatry. 2014 May;59(5):285-8. doi: 10.1177/070674371405900508.
OBJECTIVE
To examine the relation of electroencephalographic abnormalities to 5-year outcomes in first-episode psychosis (FEP).
METHODS
Patients (n = 103) had their baseline electroencephalogram (EEG) classified by modified Mayo Clinic criteria. Symptoms and psychosocial functioning were rated after 5 years of treatment.
RESULTS
Dysrhythmic EEG was associated with persistence in positive and negative symptoms of psychoses and poorer psychosocial functioning at 5-year follow-up, independently of other characteristics, such as duration of untreated illness or premorbid adjustment. A higher percentage of people with comorbid substance use disorder had normal EEG.
CONCLUSIONS
Abnormal baseline EEG in FEP is associated with poorer 5-year symptomatic and functional outcome.
目的
研究首发精神病（FEP）患者脑电图异常与 5 年结局的关系。
方法
根据改良 Mayo 诊所标准对 103 例患者的基线脑电图（EEG）进行分类。治疗 5 年后对症状和社会心理功能进行评分。
结果
节律紊乱型脑电图与精神病阳性和阴性症状的持续存在以及 5 年随访时较差的社会心理功能有关，独立于其他特征，如未治疗疾病的持续时间或病前适应。合并物质使用障碍的患者中，脑电图正常的比例更高。
结论
FEP 患者的基线脑电图异常与较差的 5 年症状和功能结局相关。
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