Guo Mei-Hua, Wu Wen-Juan, Fan Long, Peng Min-Sheng, Yang Jian-Kang, Zhang Wen, Hao Fei, Xie Hong-Fu, Xiang Lei-Hong, Zheng Min, Guo Yan-Ni, Song Qing-Hua, Tu Cai-Xia, Zhong Hua, Fan Wen-Ge, Shi Yue-Jun, Cao Ping, Feng Lian-Yuan, Na Meng, Pang Qin, Yang Xiao-Yan, Yang Cheng, Zou Xi, He Li, Zhang Ya-Ping
Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan Province, Kunming, China.
KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China.
J Hum Genet. 2014 Aug;59(8):475-6. doi: 10.1038/jhg.2014.53. Epub 2014 Jul 10.
Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.
在中国人群中，重度痤疮的发病率存在性别差异，男性更为普遍。为了评估Y染色体对汉族男性重度痤疮风险的可能影响，我们分析了从最近的全基因组关联研究数据中选取的725例重度痤疮病例和651例对照中的2041个Y染色体单核苷酸多态性（Y-SNPs）。经过数据筛选后，我们根据307个高可信度Y-SNPs将585例病例和494例对照归入12个Y染色体单倍群。病例组和对照组之间Y染色体单倍群频率分布没有观察到统计学上的显著差异。我们的结果表明，在中国汉族人群中，重度痤疮的发病率与不同的Y染色体单倍群之间缺乏关联。
