Stricker Hans
Ospedale La Carità, Locarno, Switzerland.
Vasa. 2014 Jul;43(4):239-43. doi: 10.1024/0301-1526/a000358.
A relationship between tumor and thrombosis is well known. This review covers the aspect of incidence and pathophysiology of cancer-related thromboembolism. Cancer patients have an up to 7 % risk of developing venous thrombosis, partly because they are subject to various circumstantial risk factors such as surgical interventions, immobilization or drugs during their illness. On the other hand, tumors frequently generate a prothrombotic state, which may remain without clinical manifestation or result in anticoagulant-resistent venous thromboembolism. Recently discovered thrombosis-generating mechanisms could help to classify patients in categories with high and low thrombotic risk, which will allow tailored prophylactic and therapeutic interventions.
肿瘤与血栓形成之间的关系已广为人知。本综述涵盖了癌症相关血栓栓塞的发生率和病理生理学方面。癌症患者发生静脉血栓形成的风险高达7%，部分原因是他们在患病期间会受到各种环境风险因素的影响，如手术干预、制动或药物治疗。另一方面，肿瘤经常产生促血栓形成状态，这种状态可能没有临床表现，或者导致对抗凝药物耐药的静脉血栓栓塞。最近发现的血栓形成机制有助于将患者分为高血栓形成风险和低血栓形成风险类别，这将允许进行有针对性的预防和治疗干预。
