局限性前列腺癌的质子束治疗基础：基础、争议与事实 101
Proton beam therapy for localized prostate cancer 101: basics, controversies, and facts.
作者信息
Wisenbaugh Eric S, Andrews Paul E, Ferrigni Robert G, Schild Steven E, Keole Sameer R, Wong William W, Vora Sujay A
机构信息
Department of Urology Phoenix, AZ.
Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, AZ.
出版信息
Rev Urol. 2014;16(2):67-75.
Abstract
Proton beam therapy for prostate cancer has become a source of controversy in the urologic community, and the rapid dissemination and marketing of this technology has led to many patients inquiring about this therapy. Yet the complexity of the technology, the cost, and the conflicting messages in the literature have left many urologists ill equipped to counsel their patients regarding this option. This article reviews the basic science of the proton beam, examines the reasons for both the hype and the controversy surrounding this therapy, and, most importantly, examines the literature so that every urologist is able to comfortably discuss this option with inquiring patients.
摘要
质子束疗法治疗前列腺癌已成为泌尿外科领域的一个争议来源，这项技术的迅速传播和营销导致许多患者询问这种疗法。然而，该技术的复杂性、成本以及文献中相互矛盾的信息，使得许多泌尿外科医生在为患者提供有关这一治疗选择的咨询时准备不足。本文回顾了质子束的基础科学，探讨了围绕这种疗法的炒作和争议的原因，最重要的是，对文献进行了审视，以便每位泌尿外科医生都能自如地与询问的患者讨论这一治疗选择。
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Int J Radiat Oncol Biol Phys. 2013 Sep 1;87(1):46-52. doi: 10.1016/j.ijrobp.2013.04.030. Epub 2013 Jun 15.
2
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J Natl Cancer Inst. 2013 May 15;105(10):748. doi: 10.1093/jnci/djt074. Epub 2013 Apr 3.
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