Conry Robert M
Division of Hematology & Oncology, University of Alabama at Birmingham, 2145 Bonner Way, Birmingham, AL 35243, USA.
Clin Sarcoma Res. 2014 Jun 28;4:6. doi: 10.1186/2045-3329-4-6. eCollection 2014.
Follicular dendritic cell sarcoma is a rare malignancy arising from follicular dendritic cells, which form a meshwork within lymphoid follicles. Traditional treatment of metastatic disease with CHOP chemotherapy, the most commonly used regimen for lymphoid malignancies, has met with limited success. I report herein two cases of follicular dendritic cell sarcoma metastatic to the liver treated with the combination of gemcitabine and docetaxel showing unprecedented response in this disease. These observations coupled with recent evidence of a mesenchymal origin of follicular dendritic cells support the premise that this malignancy should be treated similar to other adult soft tissue sarcomas.
滤泡树突状细胞肉瘤是一种起源于滤泡树突状细胞的罕见恶性肿瘤，滤泡树突状细胞在淋巴滤泡内形成一个网络。转移性疾病的传统治疗方法是使用CHOP化疗，这是治疗淋巴恶性肿瘤最常用的方案，但取得的成功有限。我在此报告两例转移性至肝脏的滤泡树突状细胞肉瘤患者，他们接受吉西他滨和多西他赛联合治疗后，在这种疾病中显示出前所未有的反应。这些观察结果，再加上最近关于滤泡树突状细胞间充质起源的证据，支持了这种恶性肿瘤应与其他成人软组织肉瘤采用相似治疗方法的前提。
