Koharudin Leonardus M I, Gronenborn Angela M
Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Curr Opin Virol. 2014 Aug;7:95-100. doi: 10.1016/j.coviro.2014.05.006. Epub 2014 Jul 8.
A growing class of potential antivirals encompasses carbohydrate-binding proteins, such as antibodies and lectins. They block virus entry into host target cells and halt virus transmission from virus-infected cells to non-infected cells, thereby preventing infection. Here, we review the structural basis for the anti-HIV activity of various lectins, describing their structures and determinants of high-affinity oligosaccharide binding. The mechanism of glycan recognition on the gp120 envelope protein by these antiviral lectins may therefore be exploited for developing agents and alternative strategies to prevent HIV transmission.
越来越多的一类潜在抗病毒药物包括碳水化合物结合蛋白，如抗体和凝集素。它们可阻止病毒进入宿主靶细胞，并阻止病毒从受感染细胞传播至未受感染细胞，从而预防感染。在此，我们综述了各种凝集素抗HIV活性的结构基础，描述了它们的结构以及高亲和力寡糖结合的决定因素。因此，这些抗病毒凝集素识别gp120包膜蛋白上聚糖的机制可用于开发预防HIV传播的药物和替代策略。
