臂旁外侧尾侧区域的GABAA受体激动剂可抑制脑桥-膝状体-枕叶波及其相关状态。
GABAA receptor agonist at the caudo-lateral peribrachial area suppresses ponto-geniculo-occipital waves and its related states.
作者信息
Ramírez-Salado Ignacio, Rivera-García Ana Paula, Moctezuma Javier Velázquez, Anguiano Anabel Jiménez, Pellicer Francisco
机构信息
Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, 09340, Mexico; Laboratorio de Cronobiología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, 14370, Mexico.
Laboratorio de Cronobiología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, 14370, Mexico.
出版信息
Pharmacol Biochem Behav. 2014 Sep;124:333-40. doi: 10.1016/j.pbb.2014.06.024. Epub 2014 Jul 8.
PURPOSE
In order to explore the potential role of GABA, acetylcholine and glutamate in the caudo-lateral peribrachial area (C-PBL) over Rapid-Eye-Movement sleep (REM) onset and maintenance as well as on synchronized sleep with ponto-geniculo-occipital (PGO) waves (SP) in cats, a muscimol, carbachol and L-glutamate local application was performed and behavioral states were assessed.
METHODS
Fourteen chronically implanted, adult, male cats underwent a 23 hour polysomnographic recording after 3 pharmacological manipulations: carbachol, muscimol and L-glutamate. Each cat received all three drugs randomly with a seven day interval.
RESULTS
- Carbachol increases waking, SP and REM sleep while decreases slow wave sleep (SWS). 2) Muscimol decreases SP percentage and number while increases REM sleep onset. 3) Carbachol facilitates PGO activity and increases the latency to both SWS1 and REM sleep but enhances PGO activity while muscimol decreases it.
CONCLUSIONS
Acetylcholine promotes PGO related states (SP as well as REM sleep), while GABA reduces only SP and specifically PGOs.
目的
为了探究γ-氨基丁酸（GABA）、乙酰胆碱和谷氨酸在猫快速眼动睡眠（REM）开始和维持以及与脑桥-膝状体-枕叶（PGO）波同步睡眠（SP）期间，在臂旁外侧尾侧区（C-PBL）中的潜在作用，进行了蝇蕈醇、卡巴胆碱和L-谷氨酸的局部应用，并评估行为状态。
方法
14只成年雄性慢性植入电极的猫在接受三种药理操作（卡巴胆碱、蝇蕈醇和L-谷氨酸）后进行了23小时的多导睡眠图记录。每只猫以七天的间隔随机接受所有三种药物。
结果
1）卡巴胆碱增加清醒、SP和REM睡眠，同时减少慢波睡眠（SWS）。2）蝇蕈醇降低SP百分比和数量，同时增加REM睡眠开始。3）卡巴胆碱促进PGO活动，并增加SWS1和REM睡眠的潜伏期，但增强PGO活动，而蝇蕈醇则降低PGO活动。
结论
乙酰胆碱促进与PGO相关的状态（SP以及REM睡眠），而GABA仅减少SP，特别是PGO。
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