Minois Nadège, Rockenfeller Patrick, Smith Terry K, Carmona-Gutierrez Didac
Biomedical Sciences Research Complex, University of St. Andrews, St. Andrews, United Kingdom.
Institute for Molecular Biosciences, University of Graz, Graz, Austria.
PLoS One. 2014 Jul 10;9(7):e102435. doi: 10.1371/journal.pone.0102435. eCollection 2014.
Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms. In this work, we expand spermidine's range of age-related beneficial effects by demonstrating that it is also able to improve locomotor performance in aged flies. Spermidine's mechanism of action on aging has been primarily related to general protein hypoacetylation that subsequently induces autophagy. Here, we suggest that the molecular targets of spermidine also include lipid metabolism: Spermidine-fed flies contain more triglycerides and show altered fatty acid and phospholipid profiles. We further determine that most of these metabolic changes are regulated through autophagy. Collectively, our data suggests an additional and novel lipid-mediated mechanism of action for spermidine-induced autophagy.
亚精胺是一种参与多种重要细胞功能的天然多胺，在食物或水中添加亚精胺可延长几种模式生物的寿命并增强其抗应激能力。在这项研究中，我们发现亚精胺还能改善老龄果蝇的运动能力，从而拓展了其与年龄相关的有益作用范围。亚精胺对衰老的作用机制主要与普遍的蛋白质低乙酰化有关，进而诱导自噬。在此，我们提出亚精胺的分子靶点还包括脂质代谢：喂食亚精胺的果蝇含有更多甘油三酯，且脂肪酸和磷脂谱发生改变。我们进一步确定，这些代谢变化大多是通过自噬调节的。总体而言，我们的数据表明亚精胺诱导自噬存在一种额外的、新的脂质介导作用机制。
